Table 4 Associations between genetic scores of height-related SNPs and risk of NMSCa

From: Height, height-related SNPs, and risk of non-melanoma skin cancer

  

Illumina

Affymetrix

OmniExpress

Meta-analysis b

  

Beta

s.e.

P -value

Beta

s.e.

P -value

Beta

s.e.

P -value

Beta

P -value

P for heterogeneity

Simple count genetic score

SCC

0.001

0.003

0.784

0.002

0.002

0.473

0.003

0.003

0.231

0.002

0.169

0.895

 

BCC

0.002

0.001

0.206

−0.0001

0.001

0.887

0.001

0.001

0.499

0.001

0.094

0.332

Weighted genetic score

SCC

0.001

0.003

0.815

0.002

0.002

0.454

0.004

0.003

0.120

0.002

0.125

0.767

 

BCC

0.001

0.001

0.295

2.008E-05

0.001

0.9834

0.001

0.001

0.400

0.001

0.244

0.726

  1. Abbreviations: BCC=basal cell carcinoma; NMSC=non-melanoma skin cancer; SCC= squamous cell carcinoma; SNP=single-nucleotide polymorphism.
  2. aLogistic regression models were used to assess the relationship between genetic score of height SNPs and risk of skin cancers, adjusting for age, gender, and the top three principal components.
  3. bAnalyses were first conducted within each of the platform-specific genetic data sets. We used fixed-effect meta-analysis to obtain a combined estimate.