Table 4 Excess relative risk (ERR) and relative risk (RR) of incidence and mortality of haematological malignancies related to in utero, postnatal, and continuous exposure to ionising radiation within the combined Southern Urals cohort

From: In utero exposure to radiation and haematological malignancies: pooled analysis of Southern Urals cohorts

 

N

PYAR

No. of cases

Mean exposure (Gy) a

ERR b (95% CI)

RR (95% CI)

Incidence

 In utero exposure (categorical)

      

 Reference (<1 mGy)

8 487

297 701

25

<0.001

0.00

1.00

 1–4 mGy

4 737

178 593

9

0.002

−0.42 (−0.95 to 0.63)

0.73 (0.30 to 1.64)

 5–19 mGy

2 278

81 517

6

0.011

−0.01 (−0.71 to 1.53)

1.00 (0.36 to 2.33)

 20–79 mGy

2 145

74 037

9

0.042

0.79 (−0.28 to 3.22)

1.65 (0.69 to 3.66)

 ⩾80 mGy

1 889

68 656

9

0.200

1.27 (−0.20 to 4.71)

2.17 (0.87 to 5.09)

 Postnatal exposure (categorical)

      

 Reference (<1 mGy)

 

339 539

30

<0.001

0.00

1.00

 1–19 mGy

 

186 841

14

0.007

0.31 (−0.48 to 2.06)

1.17 (0.48 to 2.79)

 ⩾20 mGy

 

174 124

14

0.220

0.44 (−0.48 to 2.46)

1.10 (0.44 to 2.60)

 Continuous exposure

      

 In utero (per 100 mGy)

19 536

700 504

58

0.026

0.77 (0.02 to 2.56)

1.30 (0.97 to 1.59)

 Postnatal (per 100 mGy)

19 536

700 504

58

0.057

0.21 (−0.05 to 1.10)

1.10 (0.92 to 1.25)

Mortality

 In utero exposure (categorical)

      

 Reference (<1 mGy)

8550

299 575

16

<0.001

0.00

1.00

 1–4 mGy

4791

179 480

6

0.002

−0.10 (−0.93 to 2.19)

1.02 (0.33 to 2.74)

 5–19 mGy

2306

82 088

5

0.011

0.57 (−0.59 to 3.77)

1.37 (0.44 to 3.60)

 20–79 mGy

2214

74 805

6

0.042

1.16 (−0.31 to 5.16)

1.69 (0.57 to 4.37)

 ⩾80 mGy

2095

70 320

3

0.201

−0.14 (−0.94 to 2.62)

0.95 (0.21 to 3.09)

 Postnatal exposure (categorical)

      

 Reference (<1 mGy)

 

343 865

20

<0.001

0.00

1.00

 1–19 mGy

 

187 285

7

0.007

0.58 (−0.62 to 4.29)

1.15 (0.35 to 3.54)

 ⩾20 mGy

 

175 119

9

0.221

0.94 (−4.30 to 4.98)

1.29 (0.40 to 3.83)

 Continuous exposure

      

 In utero (per 100 mGy)

19 956

706 269

36

0.026

0.16 (−0.09 to 1.19)

1.11 (0.67 to 1.51)

 Postnatal (per 100 mGy)

19 956

706 269

36

0.057

0.08 (−0.05 to 0.72)

1.05 (0.81 to 1.23)

  1. Abbreviations: CI=confidence interval; PYAR=person-years at risk over the period of follow-up.
  2. aPerson-year-weighted mean.
  3. bModel fit under constraint that estimated parameter is greater than −1.0 for categorical analysis or (−(maximum postnatal dose)−1) for continuous analysis; lower bound of 95% CI may be estimated at boundary of parameter space.
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