Table 3 Adjusted Cox proportional hazard analysis of PFS and OS
PFS | OS | |||
|---|---|---|---|---|
HR (95% CI) | P -value | HR (95% CI) | P -value | |
Model including only clinical characteristics | ||||
VeriStrat classification (good vs poor) | 0.32 (0.18–0.58) | 0.0002 | 0.23 (0.12–0.44) | <0.0001 |
Gender (male vs female) | 1.27 (0.72–2.24) | 0.4028 | 1.58 (0.84–2.98) | 0.1604 |
Smoking status (ever vs never) | 1.09 (0.46–2.60) | 0.8519 | 1.49 (0.58–3.81) | 0.4062 |
ECOG PS (⩾1 vs 0) | 1.10 (0.62–2.01) | 0.7213 | 1.07 (0.54–2.12) | 0.8414 |
KRAS status (mutant vs WT or unknown) | 0.98 (0.54–1.80) | 0.9505 | 1.21 (0.62–2.34) | 0.5794 |
KRAS known (known vs unknown) | 3.13 (1.41–6.95) | 0.0049 | 2.87 (1.17–7.07) | 0.0219 |
Model including clinical characteristics and treatment | ||||
VeriStrat classification (good vs poor) | 0.39 (0.22–0.71) | 0.0019 | 0.23 (0.11–0.46) | <0.0001 |
Gender (male vs female) | 1.36 (0.77–2.39) | 0.2933 | 1.68 (0.87–3.23) | 0.1220 |
Tx regimen (Cis/Pem vs Carbo/Pem) | 1.87 (1.10–3.16) | 0.0202 | 1.86 (1.05–3.32) | 0.0343 |
Smoking status (ever vs never) | 1.43 (0.58–3.56) | 0.4396 | 2.73 (0.91–8.20) | 0.0727 |
ECOG PS (⩾1 vs 0) | 1.12 (0.61–2.03) | 0.7204 | 1.00 (0.51–1.99) | 0.9976 |
KRAS status (mutant vs WT or unknown) | 1.11 (0.61–2.04) | 0.7312 | 1.26 (0.64–2.47) | 0.5032 |
KRAS (known vs unknown) | 2.31 (1.06–5.07) | 0.0363 | 1.90 (0.78–4.61) | 0.1553 |
Maintenance (yes vs no) | 0.35 (0.20–0.60) | 0.0002 | 0.27 (0.14–0.52) | <0.0001 |
