Table 5 Changes in measures of body composition by CT between pre- and post-treatment imaging in patients treated with ipilimumab

From: The impact of body composition parameters on ipilimumab toxicity and survival in patients with metastatic melanoma

   

Change

Change per 100 days

Relative change per 100 days (%)

Tissue

First CT scanMean (s.d.)

Second CT scan Mean (s.d.)

Mean

95% CI

P-value

Mean

95% CI

P-value

Mean

95% CI

P-value

Skeletal muscle area (cm2)

151.3 (37.2)

144.2 (37.2)

−7.1

−10.2 to −3.9

<0.001

−5.2

−2.9 to −7.4

<0.001

−3.3

−4.5 to −1.8

<0.001

Total adipose tissue area (cm2)

310.9 (130.7)

276.8 (131.1)

−34.1

−51.9 to −16.3

<0.001

−22.8

−11.4 to −34.2

<0.001

−6.8

−10.7 to −2.9

<0.001

FFMa (kg)

50.9 (10.6)

48.8 (10.4)

−2.1

−3.1 to −1.2

<0.001

−1.6

−0.9 to −2.3

<0.001

−3.0

−4.3 to −1.6

<0.001

FMb (kg)

24.3 (5.5)

22.8 (5.5)

−1.5

−2.2 to −0.7

<0.001

−1.1

−0.6 to −1.7

<0.001

−4.5

−2.3 to −6.7

<0.001

Muscle attenuation (HU)

40.5 (8.6)

38.8 (10.2)

−1.7

−3.8 to −0.3

0.019

−1.2

0.2 to −2.6

0.08

−3.0

−5.8 to −0.3

0.030

  1. Abbreviations: CT=computed tomography; FM=fat mass; FFM=fat-free mass; HU=Hounsfield units; s.d.=standard deviation.
  2. aFFM (kg)=0.3 × (skeletal muscle cross-sectional area at L3 (cm2))+6.06; r2=0.88.
  3. bFM (kg)=0.042 × (adipose tissue cross-sectional area at L3 (cm2))+11.2; r2=0.77.
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