Table 3 Comparison of cases and controls for candidate biomarkers according to stage, grade, node status, NPI and HER2 status

	Stage		Grade			Node status		NPI		HER2 status
Marker	Ctrl vs 1/2	Ctrl vs 3/4	Ctrl vs 1	Ctrl vs 2	Ctrl vs 3	Ctrl vs N0	Ctrl vs N1	Ctrl vs ⩽4	Ctrl vs >4	Ctrl vs neg	Ctrl vs pos
(A) All samples
CA15-3	NS	0.0215	0.0254	NS	NS	NS	NS	NS	NS	NS	NS
RANTES	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
OPN	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
IGFBP3	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
PAI-1	NS	NS	NS	NS	0.0491	NS	NS	NS	NS	NS	NS
HSP90A	NS	NS	NS	NS	0.0174	NS	NS	NS	0.0196	ns	ns
SLPI	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
PAPPA	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
APOC1	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
(B) <1.15 years to D x
CA15-3	NS	NS	NS	NS	NS	NS	0.0419	NS	NS	NS	NS
RANTES	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
OPN	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
IGFBP3	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
PAI-1	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
HSP90A	NS	NS	NS	NS	NS	NS	NS	0.0259	0.0419	NS	NS
SLPI	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
PAPPA	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
APOC1	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
(C) >1.15 years to D x
CA15-3	NS	NS	0.039	NS	NS	NS	NS	NS	NS	NS	NS
RANTES	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
OPN	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
IGFBP3	NS	NS	NS	NS	NS	NS	0.0447	NS	NS	NS	NS
PAI-1	NS	NS	NS	NS	NS	NS	NS	NS	NS	0.0391	0.0364
HSP90A	NS	NS	NS	NS	0.0079	NS	NS	NS	NS	NS	NS
SLPI	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
PAPPA	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
APOC1	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS

P-values for various comparisons are shown. P<0.05 was considered significant; NS denotes non-significance. Comparisons are shown for all pre-diagnosis case samples vs all controls (A), between case samples taken <1.15 years to diagnosis (median) and all controls (B) and between case samples taken >1.15 years to diagnosis and all controls (C).

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