Table 4 Analysis of candidate biomarkers within cases according to stage, grade, node status, NPI and HER2 status

	Stage			Grade			Node status	NPI	HER2 status
Marker	1 vs 2	1 vs 3/4	2 vs 3/4	1 vs 2	1 vs 3	2 vs 3	N1 vs N0	⩽4 vs >4	Pos vs neg
(A) All samples
CA15-3	NS	0.0001	0.0024	0.0078	NS	NS	0.036	NS	NS
RANTES	0.0232	0.0183	NS	NS	NS	NS	NS	NS	NS
OPN	NS	NS	0.0381	NS	NS	NS	NS	NS	NS
IGFBP3	NS	NS	NS	NS	NS	NS	NS	NS	NS
PAI-1	NS	NS	NS	NS	NS	0.0405	NS	0.0384	NS
HSP90A	NS	NS	NS	NS	NS	NS	NS	0.0062	NS
SLPI	NS	NS	NS	NS	NS	NS	NS	NS	NS
PAPPA	NS	NS	NS	NS	NS	NS	NS	NS	NS
APOC1	NS	NS	NS	NS	NS	NS	NS	NS	NS
(B) <1.15 years to D x
CA15-3	NS	0.0049	0.032	NS	NS	NS	0.0368	NS	NS
RANTES	NS	NS	NS	NS	NS	NS	NS	NS	NS
OPN	0.0245	NS	0.0052	NS	NS	NS	NS	NS	NS
IGFBP3	NS	NS	NS	NS	NS	NS	NS	NS	0.0037
PAI-1	NS	NS	NS	NS	NS	NS	NS	0.0331	NS
HSP90A	NS	NS	NS	NS	0.0073	NS	NS	0.0003	NS
SLPI	NS	NS	NS	NS	NS	NS	NS	NS	NS
PAPPA	NS	NS	NS	NS	NS	NS	NS	NS	NS
APOC1	NS	NS	NS	NS	NS	NS	NS	NS	NS

P-values are shown for comparisons within all pre-diagnosis case samples for the pathological features (A) and within case samples taken <1.15 years to diagnosis (B). P<0.05 was considered significant; NS denotes non-significance.

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