Table 3 Cox regression uni- and multivariate analyses of stage I and II OTSCC patients

From: Tenascin-C and fibronectin expression divide early stage tongue cancer into low- and high-risk groups

 

HR

95% CI for HR

P -value

Univariate analysis, stages I–II

 Stromal TNC

  

0.025

 Negative

1

  

 Moderate

1.09

0.39–3.07

NS

 Abundant

5.18

1.29–18.61

0.019

 Cancer cell TNC

  

NS

 Negative

1

  

 Positive

1.03

0.43–2.48

NS

 Stromal FNa

  

<0.001

 Moderate

1

  

 Abundant

6.10

2.36–15.75

<0.001

 Cancer cell FN

  

NS

 Negative

1

  

 Positive

2.30

0.99–5.33

NS

Multivariate analysis, stages I–II

 Stromal TNC

  

0.012

 Negative

1

  

 Moderate

0.76

 

NS

 Abundant

6.54

0.23–2.48

0.030

 Cancer cell TNC

  

NS

 Negative

1

  

 Positive

1.61

0.54–4.78

NS

 Stromal FNa

  

0.004

 Moderate

1

  

 Abundant

5.91

1.75–19.94

0.004

 Cancer cell FN

  

NS

 Negative

1

  

 Positive

1.56

0.61–4.04

NS

  1. Abbreviations: CI=confidence interval; FN=fibronectin; HR=hazard ratio; OTSCC=Oncology Center of Cascavel; TNC=tenascin-C.
  2. Multivariate analysis adjusted for age, gender and hospital.
  3. HR and their 95% CI, as well as P-values. Analyses were performed separately for stromal and cellular TNC and FN. In multivariate analysis the HRs were adjusted for age, gender and hospital. The HR for stromal FN in multivariate analysis was calculated by comparing abundant to moderate due to the lack of end points (cancer deaths) in the FN-negative group. Statistically significant values are bolded.
  4. aHR could not be calculated comparing with ‘Negative’ group due to lack of end points in that group.
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