Figure 1

Structure of mipsagargin. Sequential PSMA-mediated hydrolysis of mipsagargin ((8-O-(12-aminododecanoyl)-8-O-debutanoyl thapsigargin)-Asp-γ-Glu-γ-Glu-γ-GluGluOH) yields the cytotoxic thapsigargin analogue 12ADT-Asp.
Structure of mipsagargin. Sequential PSMA-mediated hydrolysis of mipsagargin ((8-O-(12-aminododecanoyl)-8-O-debutanoyl thapsigargin)-Asp-γ-Glu-γ-Glu-γ-GluGluOH) yields the cytotoxic thapsigargin analogue 12ADT-Asp.