Table 2B Mipsagargin dose levels evaluated

From: Mipsagargin, a novel thapsigargin-based PSMA-activated prodrug: results of a first-in-man phase I clinical trial in patients with refractory, advanced or metastatic solid tumours

Dose escalation (n=28)

Mipsagargin dose (mg m 2) (days 1, 2 and 3)

Number of patients

1.2

3

2.5

3

5

3

10

3

20

3

40

4

66.8

6

88

3

Dose expansion (n=16)

Mipsagargin dose (mg m 2) (day 1/day 2/day 3)

Number of patients

40/66.8/66.8

16