Table 5A Progression-free survival in patients with SD as best response

From: Mipsagargin, a novel thapsigargin-based PSMA-activated prodrug: results of a first-in-man phase I clinical trial in patients with refractory, advanced or metastatic solid tumours

Patient number

Tumour type

Dose level (mg m 2) (day 1/2/3)

Progression-free survival (days)

01–002

Prostate

1.2

112

01–006

Cholangiocarcinoma

2.5

89

01–010

Colorectal

5

112

01–012

Non-small cell lung

10

52a

01–017

Pancreas

40

57a

01–022

Adenocarcinoma

66.8

63a

03–029

Prostate

88

119

03–031

Endometrial

40/66.8/66.8

77a

03–036

Hepatocellular

40/66.8/66.8

336

03–037

Prostate

40/66.8/66.8

121a

03–043

Hepatocellular

40/66.8/66.8

133

03–044

Hepatocellular

40/66.8/66.8

277a

  1. Abbreviation: SD=stable disease.
  2. aCensored observation.