Table 3 The final multivariate model showing the significance of the differential expression of CYP4A11 and CYP4F11 in multivariate analysis for the whole patient cohort and MMR-proficient tumours

From: The differential expression of omega-3 and omega-6 fatty acid metabolising enzymes in colorectal cancer and its prognostic significance

 

Whole patient cohort

MMR-proficient tumours

 

Wald value

P -value

HR (95% CI)

Wald value

P -value

HR (95% CI)

Age (<70 vs⩾70)

31.115

<0.001

1.982 (1.554–2.529)

25.568

<0.001

1.993 (1.526–2.604)

EMVI (present vs absent)

38.825

<0.001

2.278 (1.758–2.951)

29.637

<0.001

2.245 (1.678–3.004)

Dukes stage (A vs B vs C)

53.435

<0.001

2.826 (0.762–4.191)

35.144

<0.001

2.622 (0.785–3.961)

Differential expression of CYP4A11 and CYP4F11 (CYP4A11>CYP4F11 vs CYP4A11=CYP4F11 vs CYP4A11<CYP4F11)

5.515

0.019

1.186 (1.029–1.368)

3.983

0.046

1.173 (1.003–1.371)

  1. Abbreviations: CI=confidence interval; EMVI=extramural venous invasion; HR=hazard ratio; MMR=mismatch repair protein.
  2. Significant values are highlighted in bold. Details of the intermediate steps and omnibus tests of model coefficients are shown in Supplementary Tables S12 and S13.
Back to article page