Table 2 Univariate analysis for overall survival in patients with ⩾10 CLM (original data set)

From: Long-term outcomes of patients with 10 or more colorectal liver metastases

Variables

3-year OS (%)

5-year OS (%)

MS (months)

P

Patient

    

 Sex

    

Female

46

32

34

0.22

Male

56

29

40

 

Age (years)

    

 <60

58

36

46

0.001

 ⩾60

44

21

35

 

Primary tumour

    

 Location

    

Colon

53

31

38

0.35

Rectum

48

25

34

 

Stage T

    

 T0–T2

63

26

54

0.16

 T3–T4

50

29

36

 

Lymph node

    

 N0

57

35

44

0.44

 N+

51

27

37

 

CLM characteristics

    

 Maximum tumour size

    

<40 mm

60

34

42

0.005

⩾40 mm

43

26

32

 

CEA

    

 <100 ng ml−1

56

29

42

0.02

 ⩾100 ng ml−1

37

16

32

 

CLM distribution

    

 Unilobar

53

30

38

0.67

 Bilobar

43

43

34

 

Initial resectability

    

 Unresectable

51

30

37

0.98

 Resectable

52

30

37

 

CLM occurrence

    

 Metachronous

48

36

34

0.22

 Synchronous

53

30

38

 

Extrahep. disease

    

 N

52

31

37

0.09

 Y

47

22

34

 

Management

    

 Preop. MRI

    

N

44

27

33

0.0009

Y

66

38

47

 

Preop. chemotherapy

    

 N

43

27

31

0.01

 Y

57

31

39

 

Preop. targeted therapy

    

 N

51

23

36

0.12

 Y

61

41

42

 

Response to preop. chemotherapy

    

 N

54

28

38

0.42

 Y

66

53

69

 

Portal vein embolisation

    

 N

49

35

36

0.81

 Y

56

27

40

 

Adjuvant chemotherapy

    

 N

48

30

34

0.08

 Y

55

31

40

 

Postop. targeted therapy

    

 N

54

34

40

0.97

 Y

58

27

42

 

Quality of resection

    

 R2/no resection

29

5

27

<0.0001

 R0/R1

61

39

49

 
  1. Abbreviations: CEA=carcinoembryonic antigen; CLM= colorectal liver metastases; Extrahep.=extrahepatic; MRI=magnetic resonance imaging; MS=median survival; OS=overall survival; postop.=postoperative; preop.=preoperative.
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