Table 2 Pooled and cohort-specific hazard ratios for the association between the empirical dietary inflammatory pattern (EDIP) score and incident epithelial ovarian cancer in the NHS and NHS-II^a^,^b^,^c

	EDIP quintiles (Q)
Cohort	Q1 −18.8 to <−0.73	Q2 −0.73 to <−0.21	Q3 −0.21 to <0.21	Q4 0.21 to <0.73	Q5 0.73 to 14.6	P -trend ^d
Median EDIP score	−1.17	−0.44	0.01	0.45	1.17
Pooled
No. of cases/person-years	218/682 484	197/686 193	219/690 780	188/694 786	167/700 271
Age, calendar time and cohort-adjusted HR (95% CI)	1.00	0.93 (0.77, 1.13)	1.10 (0.91, 1.33)	1.00 (0.82, 1.22)	1.04 (0.84, 1.27)	0.64
Multivariable-adjusted HR (95% CI)	1.00	0.92 (0.76, 1.12)	1.07 (0.89, 1.30)	0.98 (0.80, 1.19)	0.99 (0.80, 1.22)	0.97
Nurses’ Health Study (NHS)
No. of cases/person-years	173/390 941	153/351 940	167/319 212	135/285 323	103/234 015
Age, calendar time and cohort-adjusted HR (95% CI)	1.00	0.94 (0.75, 1.17)	1.13 (0.91, 1.39)	1.02 (0.82, 1.28)	1.02 (0.80, 1.30)	0.47
Multivariable-adjusted HR (95% CI)	1.00	0.93 (0.75, 1.16)	1.12 (0.90, 1.38)	1.02 (0.81, 1.29)	1.03 (0.80, 1.32)	0.46
Nurses’ Health Study II (NHS-II)
No. of cases/person-years	45/271 982	44/310 869	52/344 572	53/378 971	64/431 470
Age, calendar time and cohort-adjusted HR (95% CI)	1.00	0.91 (0.60, 1.38)	1.01 (0.67, 1.50)	0.94 (0.63, 1.40)	1.04 (0.71, 1.53)	0.80
Multivariable-adjusted HR (95% CI)	1.00	0.90 (0.59, 1.36)	0.98 (0.66, 1.47)	0.89 (0.59, 1.34)	0.93 (0.63, 1.39)	0.37

Abbreviations: CI=confidence interval; EDIP=empirical dietary inflammatory pattern score; HR=hazard ratio; NHS=Nurses’ Health Study; NHS-II=Nurses’ Health Study-II.
^aEDIP scores were adjusted for energy intake using the residual method. In the EDIP quintiles, lower EDIP scores indicate anti-inflammatory diets and higher scores, pro-inflammatory diets.
^bEDIP quintiles were based on the distribution in the pooled study population.
^cCox proportional hazards models were used for all analyses. Analyses were stratified by age, and calendar time, and were adjusted for parity, duration of breastfeeding, family history of breast cancer or ovarian cancer, duration of oral contraceptive use, menopausal status, postmenopausal hormone duration and type, tubal ligation, hysterectomy, body mass index, and number of supplements used; models were further stratified by cohort in the pooled analysis. Fifteen supplements were included in the variable 'number of supplements used': multivitamins, vitamin A, beta-carotene, vitamin C, vitamin D, vitamin E, vitamin B-complex, folic acid, niacin (when used separately from B-complex), calcium, iron, selenium, zinc, magnesium and fish oil.
^dContinuous residual-adjusted EDIP scores were used to test for linear trend across EDIP quartiles, adjusted for all covariates previously listed.

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