Table 1 Details of the seven patients (from 431 patients registered and tested centrally) with discrepant oestrogen receptor results

From: Discrepancies in central review re-testing of patients with ER-positive and HER2-negative breast cancer in the OPTIMA prelim randomised clinical trial

 

Central ER results

 

Patient

ER status

Allred score

% Tumour cell positivity

Comment

A

Negative

0

0

Two clonality distinct tumours – part positive and part negative for ER. Original ER on core biopsy.

B

Negative

0

0

ER repeated in local laboratory on core biopsy using different antibody/clone and negative staining for ER confirmed.

C

Negative

0

0

ER retested locally and confirmed to be negative.

D

Negative

0

0

 

E

Negative

0

0

Heterogenous tumour, at least focally ER-negative.

F

Negative

0

0

 

G

Negative

0

0

Three tumours: two eligible, one ineligible

  1. Abbreviation: ER=oestrogen receptor.