Table 2 Distributions of age accelerations based on Helicobacter pylori (HP) infection and severity of chronic atrophic gastritis (CAG)

From: Associations of Helicobacter pylori infection and chronic atrophic gastritis with accelerated epigenetic ageing in older adults

  

Age acceleration (Horvath)

Age acceleration (Hannum)

Categories

N

Median (interquartile range)

P -value a

Median (interquartile range)

P -value a

HP infection (yes/no)

  

0.004

 

0.007

No (IgG–)

712

−0.635 (−3.558 to 2.660)

 

−0.424 (−3.282 to 2.432)

 

Yes (IgG+)

765

0.218 (−2.974 to 3.383)

 

0.185 (−2.528 to 3.019)

 

HP serostatus

  

0.006

 

0.014

IgG–/CagA–

712

−0.635 (−3.558 to 2.660)

 

−0.424 (−3.282 to 2.432)

 

IgG+/CagA–

371

−0.249 (−3.107 to 2.979)

 

−0.089 (−2.541 to 2.784)

 

IgG+/CagA+

394

0.756 (−2.894 to 3.557)

 

0.450 (−2.470 to 3.102)

 

HP infection risk

  

0.005

 

0.014

Low (CagA–)

1083

−0.454 (−3.346 to 2.758)

 

−0.291 (−3.092 to 2.536)

 

High (CagA+)

394

0.756 (−2.894 to 3.557)

 

0.450 (−2.470 to 3.102)

 

CAG (yes/no)

  

0.078

 

0.015

No (non-atrophic)

1304

−0.321 (−3.316 to 2.951)

 

−0.220 (−2.972 to 2.677)

 

Yes (mild/severe atrophic)

173

0.687 (−2.975 to 3.399)

 

0.614 (−2.576 to 3.600)

 

Severity of CAG

  

0.155

 

0.024

Non-atrophic

1304

−0.321 (−3.316 to 2.951)

 

−0.220 (−2.972 to 2.677)

 

Mild atrophic

75

0.307 (−3.275 to 3.168)

 

0.151 (−3.058 to 3.243)

 

Severe atrophic

98

1.208 (−2.975 to 3.463)

 

0.897 (−2.230 to 3.927)

 
  1. Abbreviations: CAG=chronic atrophic gastritis.
  2. aTested by Wilcoxon test (binomial variables) or Kruskal–Wallis test (variables with three categories).
  3. Bold values indicate that this P-value is less than 0.05 and therefore is statistically significant.
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