Figure 2 | British Journal of Cancer

Figure 2

From: Circulating cytokines and small molecules follow distinct expression patterns in acute myeloid leukaemia

Figure 2

Cytokine and small molecule expression-based clustering. (A) Heatmap of pairwise Pearson’s correlation coefficients between analytes. Five distinct groups of analytes (Analytes 1–5) are identified. Analyte 2 is uniquely correlated to each other only, whereas Analyte 4 shows opposite trend. (B) Principal component analysis (PCA) plot of the first 2 PCs of the 32 analytes. The five groups and their colours are as defined in (A). (C) The PCA plot of the first 2 PCs of the 38 samples (AML=19, control=19). Components were calculated from the expression profiles of all 32 analytes. The AML and control groups are clearly separated. Two broad groups of AML could be inferred based on the PC2 coordinates. (D) Heatmap displaying the expression levels of 18 analytes that show bimodal distribution patterns (Bimodality Index >1.4). Unsupervised hierarchical clustering performed on patients (rows) is displayed as a dendrogram and suggests two subgroups of AML (AML1 and AML2). Five of the six AML patients with favourable karyotypes belong to the AML2 group.

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