Table 2 Univariate and multivariate Cox proportional hazard ratios for metabolites and metabolite ratios and prostate cancer recurrence following radical prostatectomy

From: Ex vivo metabolic fingerprinting identifies biomarkers predictive of prostate cancer recurrence following radical prostatectomy

 

Univariate analysis

Multivariate analysis

Multivariate analysis

   

Spermine model

tChoCre/Spm model

Variable

HR (95% CI)

P- value

HR (95% CI)

P- value

HR (95% CI)

P- value

Spermine (log2)

0.63 (0.50–0.80)

<0.001

0.72 (0.55–0.94)

0.016

  

tChoCre/Spm (log2)

1.55 (1.23–1.96)

<0.001

  

1.43 (1.08–1.91)

0.014

Citrate (log2)

0.67 (0.51–0.86)

0.002

    

tChoCre/Cit (log2)

1.38 (1.11–1.71)

0.004

    

Choline (log2)

1.59 (1.05–2.39)

0.028

    

Creatine (log2)

0.75 (0.48–1.19)

0.22

    

Age (continuous)

1.02 (0.97–1.07)

0.42

    

Preoperative PSA

1.02 (0.98–1.07)

0.329

    

Grade group (RP)

      

 1

Reference

 

Reference

 

Reference

 

 2

0.38 (0.14–1.05)

0.062

0.55 (0.18–1.70)

0.30

0.53 (0.17–1.65)

0.27

 3

0.92 (0.34–2.51)

0.87

0.83 (0.28–2.44)

0.74

0.73 (0.24–2.23)

0.59

 4

2.12 (0.67–6.71)

0.20

2.73 (0.81–9.18)

0.11

2.58 (0.76–8.72)

0.13

 5

3.01 (0.95–9.56)

0.061

2.04 (0.61–6.85)

0.25

2.00 (0.60–6.71)

0.26

EPE

4.65 (2.61–8.27)

<0.001

3.03 (1.54–5.96)

0.0013

2.98 (1.51–5.89)

0.0017

SVI

3.39 (1.76–6.54)

<0.001

1.02 (0.46–2.72)

0.95

1.06 (0.49–2.31)

0.87

PSM

1.67 (0.95–2.94)

0.074

    
  1. Abbreviations: CI=confidence interval; EPE=extraprostatic extension; HR=hazard ratio; PSA=prostate-specific antigen; PSM=positive surgical margins; RP=radical prostatectomy; SVI=seminal vesicle invasion; tChoCre/Cit=(total-choline+creatine)/citrate; tChoCre/Spm=(total-choline+creatine)/spermine.
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