Table 3 C-index for univariate and multivariate models including spermine and the tChoCre/Spm metabolite ratio

From: Ex vivo metabolic fingerprinting identifies biomarkers predictive of prostate cancer recurrence following radical prostatectomy

 

Univariate analysis

 

Multivariate analysis

Variable

C-index

 

C-index

LOOCV C-index a

ΔC-index

Spermine (log2)

0.667

Full models

0.769

0.769

0.020

tChoCre/Spm (log2)

0.660

 

0.765

0.765

0.016

Grade group (RP)

0.694

Basic model

0.749

0.749

 

EPE

0.697

    

SVI

0.595

    
  1. Abbreviations: C-index=concordance index; EPE=extraprostatic extension; LOOCV=leave-one-out cross-validated; RP=radical prostatectomy; SVI=seminal vesicle invasion; tChoCre/Spm=(total-choline+creatine)/spermine.
  2. Grade group was categorised from 1 to 5. Full model refers to models containing metabolites on top of the basic model, whereas basic model refers to the pathological model without added metabolites.
  3. aLOOCV C-indexes were used to calculate the change in C-index upon adding either spermine or tChoCre/Spm to the basic model (ΔC-index).
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