Table 2 Age-dependent incidence rate ratios for extra-colonic cancer in Lynch syndrome mutation carriers

From: Towards gene- and gender-based risk estimates in Lynch syndrome; age-specific incidences for 13 extra-colorectal cancer types

 

Lynch syndrome vs population-based cohort

Cancer

Age groups

IRR

95% CI lower

95% CI upper

P-values

Endometrial cancer (n=163)

0–29

0

0

278.7

1

 

30–49

133.0

96.2

178.9

<0.0001

 

50–69

27.4

20.7

35.5

<0.0001

 

70+

4.6

0.8

14.1

0.01218

Urothelial cancer (n=75)

0–29

34.2

2.0

154.7

0.00165

 

30–49

8.3

2.8

18.9

<0.0001

 

50–69

8.2

5.5

11.7

<0.0001

 

70+

7.1

3.6

12.5

<0.0001

Breast cancer (n=47)

0–29

6.7

0.0

48.2

0.13853

 

30–49

1.7

0.8

3.1

0.05996

 

50–69

1.9

1.1

3.0

0.00224

 

70+

1.2

0.2

3.6

0.59032

Non-melanoma skin tumours (n=39)

0–29

0

0

89.2

1

 

30–49

17.8

6.4

38.9

<0.0001

 

50–69

11.0

6.0

18.3

<0.0001

 

70+

4.2

1.4

9.5

0.00086

Ovarian cancer (n=30)

0–29

0

0

41.9

1

 

30–49

24.4

13.9

39.6

<0.0001

 

50–69

2.0

0.5

5.6

0.10343

 

70+

0

0

7.4

1

Prostate cancer (n=24)

0–29

0

0

14 505.7

1

 

30–49

0

0

37.2

1

 

50–69

2.5

1.3

4.5

0.00059

 

70+

1.5

0.5

3.7

0.23773

Small bowel cancer (n=19)

0–29

0

0

737.4

1

 

30–49

107.3

35.7

245.7

<0.0001

 

50–69

32.3

11.6

70.4

<0.0001

 

70+

18.1

1.1

81.6

0.00567

Lung cancer (n=23)

0–29

0

0

136.8

1

 

30–49

3.5

1.1

8.3

0.00471

 

50–69

1.0

0.4

1.8

1

 

70+

0.4

0.0

1.6

0.19510

Gastric cancer (n=21)

0–29

0

0

226.0

1

 

30–49

8.0

1.4

24.7

0.00172

 

50–69

6.1

2.6

12.1

<0.0001

 

70+

5.2

1.2

14.4

0.00304

Brain tumours (n=21)

0–29

1.8

0.1

8.0

0.30849

 

30–49

3.6

1.4

7.6

0.00061

 

50–69

2.6

0.9

5.6

0.00984

 

70+

0

0

5.6

1

Kidney cancer (n=13)

0–29

0

0

58.9

1

 

30–49

1.7

0.0

11.9

0.45410

 

50–69

4.7

1.8

9.9

0.00007

 

70+

2.6

0.2

11.8

0.17865

Pancreatic cancer (n=13)

0–29

0

0

573.5

1

 

30–49

2.3

0.0

16.7

0.34888

 

50–69

2.8

0.8

6.6

0.01541

 

70+

3.7

0.9

10.4

0.01182

Eye tumours (n=3)

0–29

0

0

85.5

1

 

30–49

14.5

0.8

65.4

0.00869

 

50–69

4.0

0.0

28.9

0.21992

 

70+

0

0

68.0

1

  1. Abbreviations: CI=confidence intervals; IRR=incidence rate ratio.
  2. Incidence rates and 95% CI for the Lynch syndrome cohort and the population-based cohort are shown in Supplementary Table 2. Bold P values indicate significance following Bonferroni correction.
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