Figure 2
From: Dual roles of tumour cells-derived matrix metalloproteinase 2 on brain tumour growth and invasion
Effects of MMP2 inhibition on cell proliferation, cell invasion, and the survival of brain tumour-bearing mice. (A) In vitro cell proliferation rate had no difference between ALTS1C1 and MMP2kd cells. (B) MMP2 knockdown altered the invasive ability of ALTS1C1 cells, but not the migration ability. (C) Kaplan–Meier survival curves of ALTS1C1 (n=18) and MMP2kd (n=11) tumour-bearing mice. (D) Representative fluorescent images of MMP2 and DAPI staining in ALTS1C1 and MMP2kd tumours. Scale bar: 50 μm. *P<0.05, ****P<0.0001.
