Table 3 TERT mutation status in 10 discordant cases with wild type first metastasis and a mutation-positive primary tumour

Case	First appearing metastasis (different part of tumour)			Second appearing metastasis			Third appearing metastasis
	TERT	Location	Synchronous/metachronous^a	TERT	Location	Synchronous/metachronous^b	TERT	Location	Synchronous/metachronous^c
558^d	Mutated	Lymph node	Metachronous	Mutated	Skin	Synchronous	Mutated	Skin	Synchronous
567^e	Wild type	Skin	Metachronous	Mutated	Skin	Metachronous
569^e	Mutated	Skin	Metachronous
582^e	Wild type	Lymph Node	Synchronous
615^d	Mutated	Skin	Metachronous
641^d	Wild type	Lymph Node	Metachronous
668^e	Wild type	Skin	Metachronous	Wildtype	Skin	Metachronous
675^d	Wild type	Skin	Synchronous
699^e	Wild type	Lymph Node	Synchronous	Mutated	Skin	Metachronous	Mutated	Skin	Metachronous
729^d	Mutated	Lymph Node	Metachronous

Abbreviation: FFPE=formalin-fixed paraffin-embedded.
^aCompared with primary tumour.
^bCompared with first appearing metastasis.
^cCompared with second appearing metastasis.
^dTumour tissue from another FFPE block of the tumour than originally tested.
^eTumour tissue from a deeper level of the tumour in the same FFPE block as originally tested.

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