Table 3 Overall toxicities at the recommended dose in phases I and II of the study (N=52)

From: S-1 chemotherapy and intensity-modulated radiotherapy after D1/D2 lymph node dissection in patients with node-positive gastric cancer: a phase I/II study

Toxicity

Grades 1–2 ( N, %)

Grades 3–4 ( N, %)

Nausea

33 (63.5)

5 (9.6)

Vomiting

12 (23.1)

3 (5.7)

Anorexia

30 (57.7)

5 (9.6)

Oesophagitis

10 (19.2)

2 (3.8)

Diarrhoea

2 (3.8)

0

Abdominal pain

2 (3.8)

0

Stomatitis

13 (25.0)

1 (1.9)

Fatigue

29 (55.8)

1 (1.9)

Weight loss

6 (11.5)

0

HFS

4 (7.7)

0

Leukopenia

37 (71.1)

6 (11.5)

Neutropenia

25 (48.1)

2 (3.8)

Anaemia

11 (21.2)

0

Thrombocytopenia

27 (51.9)

0

ALT/AST

1 (1.9)

0

  1. Abbreviations: ALT=alanine aminotransferase; AST=aspartate aminotransferase; HFS=hand foot syndrome.