Figure 2

Synergistic antitumour effects of IFN α and EGFR-targeted therapies in vitro. Effects of treatments with combination of IFNα+erlotinib or nimotuzumab on HN4 and HN30 cell lines. The CI/fractional effect curve (Fa) showed the CI versus the fraction of cells affected/inhibited by the combination treatment in different cell lines. For each cell line, the molar ratio of equipotent doses of the two agents (at the ratio of their IC50S) is shown. The combination analysis was performed using CompuSyn software.