Table 5b Summary of previous published data on TERT promoter mutations in FAs and PTs

From: MED12, TERT promoter and RBM15 mutations in primary and recurrent phyllodes tumours

Publication

Number of PTs in the study

Frequency in FAs

Frequency in benign PTs

Frequency in Bo PTs

Frequency in malignant PTs

Frequency in PTs that recurred vs none recurrent cases

Evidence of acquisition of mutations in recurrent PTs

Evidence of heterogeneity in synchronous PTs/FAs

Liu et al (2016)

30

NA

0%

33%

60%

NA

NA

NA

Piscuoglio et al (2016)

76

NA

18%

57%

68%

NA

NA

NA

(Yoshida et al 2015a, 2015b)

46

7%

50%

87%

62%

NA

NA

NA

Current study

75 primary 21

recurrences

0%

31%

55%

48%

28 vs 50%

Yes

No

  1. Abbreviations: FA=fibroadenoma; NA=not assessed; PT=phyllodes tumour.