Table 1 Characteristics of all Hodgkin lymphoma patients and patients with SMN and/or CVD

From: High burden of subsequent malignant neoplasms and cardiovascular disease in long-term Hodgkin lymphoma survivors

	Total cohort ( n =2908)		Patients with SMN or CVD^a (n =1247)		Patients with SMN and CVD ( n =240)
	N	%	N	%	N	%
Sex
Male	1636	56.3	684	54.9	112	46.7
Female	1272	43.7	563	45.2	128	53.3
Age at first HL treatment (years)
Median (IQR)	27.3	21.6–35.3	28.9	22.3–37.5	30.4	23.3–37.4
<25	1165	40.1	445	35.7	79	32.9
25–34	987	33.9	411	33.0	79	32.9
35–50	756	26.0	391	31.4	82	34.2
Treatment period
1965–1976	786	27.0	493	39.5	118	49.2
1977–1988	1077	37.0	530	42.5	103	42.9
1989–2000	1045	35.9	224	18.0	19	7.9
Follow-up time (years)
Median (IQR)	21.8	15.9–29.4	25.7	18.8–32.9	29.9	24.3–37.3
5–9	280	9.6	72	5.8	4	1.7
10–19	985	33.9	292	23.4	29	12.1
20–29	957	32.9	457	36.7	90	37.5
30–39	547	18.8	327	26.2	79	32.9
⩾40	139	4.8	99	7.9	38	15.8
Treatment category
Radiotherapy only	789	27.1	434	34.8	105	43.8
Chemotherapy only	202	7.0	51	4.1	4	1.7
Radiotherapy and chemotherapy	1917	65.9	762	61.1	131	54.6
Relapse
Yes	835	28.7	377	30.2	69	28.7
No	2073	71.3	870	69.8	171	71.3
Radiotherapy fields ^b
Limited radiation fields	146	5.0	31	2.5	3	1.3
Inverted-Y	133	4.6	43	3.5	6	2.5
Incomplete mantle field	470	16.2	131	10.5	22	9.2
Mantle field	713	24.5	383	30.7	83	34.6
Incomplete subtotal nodal	237	8.2	92	7.4	15	6.3
Subtotal nodal	747	25.7	409	32.8	87	36.3
Total nodal	203	7.0	96	7.7	18	7.5
Fields unknown	57	2.0	11	0.9	2	0.8
No radiotherapy	202	7.0	51	4.1	4	1.7
Chemotherapy
No anthracyclines	961	33.1	487	39.1	99	41.3
Anthracyclines	1158	39.8	326	26.1	36	15.0
Median dose (IQR), mg m⁻²	210	150–280	210	210–300	280	210–300
No procarbazine	581	20.0	249	20.0	50	20.8
⩽4.2 g m⁻² procarbazine dose	612	21.1	188	15.1	20	8.3
>4.2 g m⁻² procarbazine dose	926	31.8	376	30.2	65	27.1
No chemotherapy	789	27.1	434	34.8	105	43.8

Abbreviations: CVD=cardiovascular disease; HL=Hodgkin's lymphoma; IQR=interquartile range; SMN=subsequent malignant neoplasm.
^aAlso includes patients with a subsequent malignancy and cardiovascular disease. Patients may have been diagnosed with multiple subsequent malignancies and/or cardiovascular diseases.
^bLimited radiation fields included small radiation volumes including supra- or infraclavicular field, inguinal field, or iliac field only. Incomplete mantle field was defined as irradiation above the diaphragm including the mediastinum or the axilla. Incomplete subtotal nodal included the combination of incomplete mantle field with radiation fields below the diaphragm or the combination of mantle field with an inguinal and/or iliac field.

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Table 1 Characteristics of all Hodgkin lymphoma patients and patients with SMN and/or CVD

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