Figure 2

SLUG and KIT siRNA silencing in GIST cell lines.An example of SLUG, KIT and actin expression after siRNA transfection in the GIST882 (A) and the GIST48 (B) cell line. Cell proliferation decreased (C, D) and the rate of cell death (E, F) increased in the GIST882 cell line and in the GIST48 cell line after transfection with KIT or SLUG siRNA. An efficacy of imatinib in the GIST882 cell line was enhanced by the downregulation of SLUG expression (G). The simultaneous downregulation of SLUG expression and KIT inhibition sensitised GIST882 cells to lower imatinib concentration (H).