Table 1 Summary of published cases of donor cell-derived hematological malignancies after CBT
From: Donor cell-derived myelodysplastic syndrome after cord blood transplantation
Author (reference no.) | Age/ sex | Conditioning regimen | GVHD prophylaxis | Disease at CBT | Duration | Donor cell-derived disease | Chromosomal abnormalities of donor cell-derived disease | Methods used to diagnose donor origin | Outcome |
|---|---|---|---|---|---|---|---|---|---|
Matsunaga et al.3 | 57/F | Flu+ATG+mPSL | FK506+mPSL | ATL | 256 days | AML | add(19) | FISH, STR | Death of DCL |
Fraser et al.4 | 1/M | BU+CY+VP-16+ATG | CsA+mPSL | Langerhan's cell histiocytosis | 40 months | AML | der(7)t(1;7) | G-banding, VNTR | Death of DCL |
Ando et al.5 | 32/F | TBI+Ara-C+CY | CsA+MTX | AML | 11 months | AML | Normal karyotype | STR | Death of TMA after second SCT |
Sevilla et al.6 | 4/F | BU+CY+ATG+TT | CsA+PSL | AML | 80 days | MDS | Monosomy 7 | STR | Transient MDS |
Mitsui et al.7 | 41/M | CY+TBI | CsA+MTX | ALL with t(9;22) | 9 months | CMPD | t(7;11) | G-banding | Free of disease after second SCT |
Inoue et al.8 | 32/F | Myeloablative regimen including TBI12Gy | CsA+MTX | AML with t(8;21) | 15 months | AML | NA | FISH | NA |
Hamaki et al.9 | 31/M | Flu+BU+TBI | CsA+MMF | Hodgkin's lymphoma | 16 months | AML | 11q23 abnormalities and monosomy 7 | STR | Death of DCL |
Our case (2008) | 34/M | TBI+Ara-C+CY | CsA+MTX | ALL | 10 months | MDS | del(6q) and monosomy 7 | STR | Death of VOD after second SCT |
