Table 1 Characteristics of and treatments received by patients

From: Graft-vs-tumor effect in patients with advanced nasopharyngeal cancer treated with nonmyeloablative allogeneic PBSC transplantation

ID

Age (year)

Sex

HLA typing

PS

No. of disease sites

Site of disease

Total no. of CT lines

Previous RT status

Disease status at accrual

Best overall response

Time to tumor response (days)

Duration of response (days)

Time to tumor progression (days)

Survival time (days)

 1a

37

M

6/6

1

4

PNS, bone, lung, LN

3

Y

PD

NE

  

186

186b

 2a

49

M

6/6

2

3

Liver, bone, LN

1

Y

PD

PD

  

84

117b

 3a

54

M

6/6

1

2

Liver, LN

1

N

SD

PD

  

94

754b

 4a

34

F

6/6

1

2

Lungs, LN

2

Y

SD

PR

41

119

160

194b

 5a

38

M

6/6

0

4

Pleural, lung, spleen, bone

5

Y

PR

NE

  

91

91c

 6a

57

M

6/6

1

3

LN, lung, liver

1

Y

PD

SD

  

110

513b

 7a

44

F

6/6

0

3

LN, lung, bone

1

Y

PD

PR

662

211

118

1014b

 8a

51

M

5/6

1

4

Liver, lung, bone, LN

1

Y

SD

NE

  

54d

226b

 9a

45

F

6/6

1

4

PNS, cx-LN, retroph-LN, bone

3

Y

PD

SD

  

344

426b

10a

43

M

6/6

1

3

Lung, bone, liver

3

Y

PD

PD

  

57

236b

11e

49

F

6/6

2

4

Lung, bone, liver, pleural

3

Y

PD

PD

  

72

107b

12e

40

M

6/6

0

3

Liver, LN, PNS

3

Y

PD

PD

  

57

211b

13e

51

M

6/6

1

3

PNS, liver, lung

2

Y

PD

PR

36

64

100

209b

14e

46

M

6/6

2

4

LN, pleural, bone, dermis

8

Y

PD

PR

57

71

128

128f

15e

48

F

6/6

1

4

Liver, LN, lung, bone

2

Y

PD

PD

  

58

114b

16e

49

M

6/6

1

4

Lung, BM, bone, LN

1

Y

PD

PR

129

396

525

774b

17e

55

M

6/6

1

5

Liver, bone, LN, lung, spleen

2

Y

PD

PD

  

66

210b

18e

45

M

6/6

1

2

Lung, LN

2

Y

PD

PR

26

77

103

1147g

19e

49

M

5/6

1

4

PNS, LN, bone, liver

3

Y

PD

PR

101

36

137

137f

20e

48

F

6/6

2

4

SVCO, lung, liver, LN

5

Y

PD

SD

  

142d

143b

21e

44

M

6/6

1

3

LN, liver, bone

3

Y

PD

NE

  

4

4h

  1. Abbreviations: CT=chemotherapy; cx=cervical; F=female; LN=lymph nodes; M=male; N=no; NE=not evaluable; PD=progressive disease; PNS=posterior nasal space; PR=partial response; PS=performance status according to Eastern Cooperative Oncology Group criteria; retroph=retropharyngeal; RT=radiotherapy; SD=stable disease; SVCO=superior vena cava obstruction; Y=yes.
  2. Note: Time to tumor response, time to tumor progression and survival time were calculated from the date of transplantation.
  3. aTreated with regimen 1: thymoglobulin at 2.5 mg/kg/day on day −1, +1, +3 and +5.
  4. bDied due to progressive disease.
  5. cDied due to acute GVHD.
  6. dDisease progression detected during clinical examination.
  7. eTreated with regimen 2: thymoglobulin at 2.5 mg/kg/day on day −1, +1, +2 and +3.
  8. fDied due to infection.
  9. gAlive.
  10. hDied due to pulmonary embolism.