Table 2 Characteristics of cellular products and kinetics of donor chimerism
Cord blood unit | Third-party donor (TPD) | Chimerism analysis (CBU/TPD/Host) a | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HLA matching | HLA mM direction | TNC × 10 7 /kg | CD34 × 10 5 /kg | CFU × 10 4 /kg | Donor | CD34 × 10 6 /kg | CD3 × 10 4 /kg | 2 weeks | 1 month | 3 months | 6 months | 12 months | ||
GVH | Rejection | |||||||||||||
1 | 3/6 | 3 | 3 | 3.71 | 1.15 | 3.63 | Sister | 4.46 | 0.15 | 33%/67%/− | >95%/<5%/− | 100%/−/− | 100%/−/− | 100%/−/− |
2 | 3/6 | 3 | 3 | 2.05 | 1.8 | 1.68 | Daughter | 11.90 | 0.80 | 12%/63%/25% | 62%/24%/14% | 100%/−/− | 100%/−/− | 100%/−/− |
3 | 4/6 | 2 | 2 | 2.62 | 0.84 | 6.8 | Daughter | 3.68 | 0.15 | 31%/69%/− | >95%/<5%/− | 100%/−/− | 100%/−/− | n/a |
4 | 5/6 | 1 | 1 | 1.96 | 0.98 | 2.6 | Daughter | 4.47 | 0.20 | 14%/86%/− | n/a | 50%/50%/− | 90%/10%/− | 100%/−/− |
5 | 4/6 | 2 | 2 | 5.8 | 1.68 | 0.95 | Sister | 4.96 | 0.40 | −/100%/− | <5%/>95%/− | 53%/47%/− | 100%/−/− | 100%/−/− |
6 | 4/6 | 2 | 2 | 3.43 | 0.81 | 1.72 | Sister | 5.89 | 0.40 | 6%/94%/− | 75%/25%/− | 100%/−/− | 100%/−/− | 100%/−/− |
7 | 4/6 | 2 | 2 | 2.31 | 0.35 | 1.56 | Brother | 3.62 | 0.73 | 10%/90%/− | 75%/23%/<5% | 49%/46%/5% | 95%/5%/− | >95%/<5%/− |
8 | 4/6 | 2 | 2 | 3.05 | 1.34 | 2.46 | Brother | 5.99 | 0.50 | 8%/92%/− | 49%/51%/− | 100%/−/− | 100%/−/− | 100%/−/− |
9 | 4/6 | 2 | 0 | 2.39 | 0.7 | No | Brotherb | 3.88 | 0.23 | n/a | 16%/84%/− | 90%/10%/− | 95%/5%/− | >95%/<5%/− |
10 | 4/6 | 2 | 1 | 1.8 | 0.41 | 1.42 | Sister | 5.3 | 0.12 | <5%/>95%/− | −/100%/− | −/100%/− | −/100%/− | −/100%/− |
11 | 4/6 | 2 | 2 | 1.39 | 0.62 | 2.26 | Sister | 4.08 | 0.18 | −/100%/− | 14%/86%/− | 79%/21%/− | 91%/9%/− | >95%/<5%/− |
12 | 4/6 | 1 | 2 | 2.96 | 2.26 | 8.02 | Brother | 5.13 | 0.60 | 21%/79%/− | 28%/72%/− | 88%/12%/− | n/a | n/a |
13 | 5/6 | 1 | 1 | 2.84 | 1.73 | 2.95 | Sister | 6.19 | 0.40 | 7%/93%/− | 23%/77%/− | 86%/14%/− | n/a | n/a |
