Table 1 Patients’ characteristics and results

From: Long-term remission after high-dose chemotherapy followed by auto-SCT as consolidation for intravascular large B-cell lymphoma

Case

At diagnosis

At auto-PBSCT

Complications

Survival

Survival status

 

Age

Gender

IPI

Stage

Extranodal lesion

HPS

Initial treatment

CNS prophylaxis

Year

Months from diagnosis

Disease status

High-dose chemotherapy

 

months from auto-PBSCT

 

1

68

M

High

IV

Lung, BM

No

R-THP-COP

No

2012

7.1

CR

Carboplatin+ Ara-C + VP16

 

12

Alive

2

53

F

High

IV

CNS, Spleen, BM

Yes

R-CHOP

Yes

2012

6.8

CR

R-MCEC

LON

16

Alive

3

43

M

High

IV

Lung, Spleen, BM

Yes

R-CHOP

Yes

2010

5.6

CR

R-MCEC

Heart failure LON

43

Alive

4

68

M

High-I

IV

Lung

No

R-THP-COP

No

2008

8.0

CR

Ara-C + L-PAM

 

70

Alive

5

61

M

High

IV

Liver, Spleen, BM

No

R-CHOP

No

2005

7.4

CR

R-MCEC

Secondary MDS LON

96

Alive

6

62

M

High

IV

Liver, Spleen, BM

Yes

R-CHOP

No

2005

5.8

CR

R-MCEC

LON

99

Alive

  1. Abbreviations: auto-PBSCT=autologous PBSC transplantation; CNS=central nervous system; HPS=hemophagocytic syndrome; IPI=international prognostic index; LON=late-onset neutropenia; L-PAM=melphalan; MDS=myelodysplastic syndrome; R-CHOP=rituximab-CHOP; R-THP-COP=rituximab/pirarubicin/CY/VCR/prednisolone; R-MCEC=rituximab/ranimustine/carboplatin/etoposide/CY. Rituximab: 375 mg/m2 for 2 days (day −9 and day +1); Ranimustine: 200 mg/m2 for 2 days; Carboplatin: 300 mg/m2 for 4 days; Etoposide: 500 mg/m2 for 3 days; CY: 50 mg/kg for 2 days; Ara-C: 2 g/m2 for 2 days; L-PAM: 60 mg/m2 for 3 days.