Figure 5

Correlation of dose adjustment in (a) and Css in (b) with aGvHD I–IV or aGvHD II–IV and graft failure (a). Presence and absence of a given complication is denoted by + and – sign, respectively. The dose adjustment is depicted by the ratio of adjusted vs unadjusted dose. Mean±SD values for dose adjustment are shown as horizontal lines across each group and for aGvHD I–IV are 1.02±0.29 (−) and 1.24±0.03 (+); for aGvHD II–IV are 1.04±0.26 (−) and 1.49±0.50 (+); and for graft failure are 1.13±0.29 (−) and 0.88±0.21 (+). (b) Css is presented as categorical variable with Css <600 ng/mL, from 600 to 900 ng/mL and >900 ng/mL. The number of individuals represented for each genotype group as well as P-values for the difference across groups is given on each plot.