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T-cell depletion: from positive selection to negative depletion in adult patients

Bone Marrow Transplantation volume 50, pages S11–S13 (2015)Cite this article

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Abstract

Clinical trials have shown that a strategy for haploidentical transplantation based on the infusion of high numbers of T-cell-depleted hematopoietic progenitor cells and no post-transplant immunosuppression controls graft rejection and GvHD in patients with acute leukemia. Overall, event-free survival compares favorably with reports of transplants using sources of stem cells other than the matched sibling. Current studies are focussing on rebuilding post-transplant immunity to improve clinical outcomes separating GvHD from favourable donor immune responses.

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Authors and Affiliations

  1. Department of Clinical and Experimental Medicine, University of Parma, Ospedale Maggiore, Via Gramsci 14, Parma, Italy

    F Aversa

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  1. F Aversa
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Correspondence to F Aversa.

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Competing interests

FA has received consulting fees from Gilead, MSD, Pfizer, Genzyme, and received lecture fees from Gilead, MSD, Pfizer and Celgene.

Additional information

This article was published as part of a supplement, supported by WIS-CSP Foundation, in collaboration with Gilead, Milteny Biotec, Gamida cell, Adienne Pharma and Biotech, Medac hematology, Kiadis Pharma, Almog Diagnostic.

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Aversa, F. T-cell depletion: from positive selection to negative depletion in adult patients. Bone Marrow Transplant 50 (Suppl 2), S11–S13 (2015). https://doi.org/10.1038/bmt.2015.88

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