Table 1 Patient characteristics
Patient characteristics | Number (%) | Univariate analysis | Multivariate analysis |
|---|---|---|---|
No. of patients | 84 (100) | ||
Age (years) | P=0.886 | ||
Median | 48.7 | ||
>60 | 8 (9) | ||
<60 | 76 (91) | ||
Sex | P=0.538 | ||
Male | 46 (55) | ||
Female | 38 (45) | ||
Diagnosis | P=0.786 | ||
De novo AML | 67 (80) | ||
sAML | 17 (20) | ||
Cytogenetic risk (ELN) | P=0.125 | ||
Favorable | 9 (11) | ||
Intermediate I | 16 (19) | ||
Intermediate II | 25 (30) | ||
Adverse | 34 (40) | ||
Stage at transplantation | P=0.005 | P=0.292 | |
First CR | 13 (15) | ||
Second CR | 12 (14) | ||
Primary refractory | 31 (37) | ||
Refractory relapse | 28 (34) | ||
Extramedullary disease | 24 (29) | P< 0.001 | P=0.981 |
Time | |||
Present at transplantation | 17 | P< 0.001 | P=0.008 |
Present at relapse after transplantation | 4 | ||
Present at first relapse before transplantation | 1 | ||
Only present at diagnosis | 1 | ||
Localized | |||
Chloroma | 7 (25) | ||
Meningeosis | 16 (67) | ||
Chloroma and meningeosis | 2 (8) | ||
GvHD | |||
cGvHD | 32 (38) | ||
Skin | 21 (25) | ||
Gastrointestinal | 11 (13) | ||
aGvHD | 44 (52) | ||
Skin | 19 (22) | ||
Gastrointestinal | 25 (30) | ||
Donor | P=0.984 | ||
Family donor | 16 (19) | ||
Unrelated donor | 56 (67) | ||
Unrelated HLA-mismatch donor | 12 (14) | ||
Prior transplantation | 5 | ||
Allogeneic HSCT | 4 | ||
Autologous HSCT | 1 | ||
Cause of death | |||
Leukemia related | 34 (57) | ||
Non-leukemia mortality | 22 (37) | ||
Unknown | 4 (6) | ||
