Figure 3
From: LRP6 in mesenchymal stem cells is required for bone formation during bone growth and bone remodeling
Mice with LRP6 deletion in nestin+ MSCs exhibit low bone mass in cortical bone. (a) Representative µCT images of cross-sections of femoral mid-diaphyses from 3 month-old male Lrp6+/+ , Lrp6+/− and Lrp6−/− mice. Scale bar=500 µm. (b–d) quantitative analysis of cross-sections of femoral mid-diaphyses from 3-month-old male Lrp6+/+ , Lrp6+/− and Lrp6−/− mice. Total area with the periosteal circumference (TA) (b), cortical bone area (BA) (c) and cortical bone thickness (Co.Th) (d). (e) Representative µCT images and quantitative analysis of cross-sections of femoral mid-diaphyses from 3-month-old female mice. Scale bar=500 µm. (f–h) quantitative analysis of cross-sections of femoral mid-diaphyses from 3-month-old female Lrp6+/+ , Lrp6+/− and Lrp6−/− mice. Total area with the periosteal circumference (TA) (f), cortical bone area (BA) (g) and cortical bone thickness (Co.Th) (h). n=10, *P<0.01, **P<0.001, vs. Lrp6+/+ group.
