Figure 7
Overview of the mechanism of juxtacrine interactions of BMSCs and macrophages on BMSC migration and cell numbers. In the bone marrow environment, macrophages differentiate into osteoclasts and BMSCs differentiate into osteoblasts. The juxtacrine interaction of BMSCs and macrophages in the local bone marrow environment induced IL-6 production by BMSCs thus accelerating BMSC migration and increasing cell numbers. The juxtacrine interaction of BMSCs and macrophages accelerated BMSC migration and increased BMSC numbers through activation of the IL-6/gp130/STAT3 pathway.
