Table 2 Regulatory functions of microRNA in Osteoblast differentiation
From: TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation
miRNA (s) | Function(s) | Reference (s) |
|---|---|---|
miR-31 | Controls cytoskeleton organization in osteoclasts for optimal bone resorption activity | |
miRNA-34c | Regulates Notch signaling during bone development, and decrease osteoporosis | |
miR-210 | Acts as a positive regulator of osteoblastic differentiation by inhibiting the TGF-β/activin signaling through inhibition of AcvR1B | |
miR-20a | Increases BMP signaling by targeting antagonists of the pathway | |
miR-21 | Promotes osteogenic and adipogenic differentiation of hMSCs | |
miR-24, 125b, 138 | Enhance osteogenic differentiation | |
miR-27 | miR-27 expression increases during differentiation of human osteoblasts and enhances Wnt signaling by repressing APC | |
miR-29b, miR-2861 | Increases osteoblast differentiation in pre-osteoblasts by repressing inhibitors of osteogenesis. Promotes BMP2 induced ST2 osteoblast differentiation by repressing histone deacetylase 5 (HDAC5) expression | |
miR-208 | Enhances BMP2 induced pre-osteoblast differentiation by targeting transactivation of osteopontin and Runx2 | |
miR-29c | Promotes Wnt signaling in osteoblasts by targeting inhibitors | |
miR-196a | Overexpression in adipose derived MSCs promotes osteoblast differentiation | |
hsa-miR-148b | Up-regulate osteoblast differentiation | |
miR-335-5p | Stimulates Wnt signaling is in mature osteoblasts and regulates Runx2 in MSCs | |
miR-378 | Promotes osteoblast differentiation by binding with nephronectin | |
miR-2861/miR-3960 | Repress Runx2 activity in a feed-forward loop | |
miR-199a, miR-346 | Regulate LIF expression during hMSC differentiation | |
miR-33a, 204, 211 | Suppressor of osteoclast function | |
miR-10b, miR-218 | Activator of bone metastases development | |
miRNAs:miR-9 | Down regulates muscle transcription factors and thus promotes osteogenesis | |
miR-191, 449a, 491, 365, 95 and miR-425 | Involves in NF-κB regulation to promote osteoblast differentiation | |
11 miRs | Overexpression inhibits/delays osteoblast differentiation | |
miR-326 | Activator of osteoclast function | |
miR-29a,b | Attenuates collagen synthesis in mineralized bone | |
miR-637 | Promotes adipocyte and inhibits osteoblast differentiation via osterix | |
miR-23a-27a-24-2, 30c, 34c, 133a, 135a, 137, 204, 205, 217, 338 | Decrease expression of Runx2 protein resulting inhibition of osteoblast differentiation | |
miR-100 | Inhibits osteoblast differentiation in hACSs | |
miR-133, 135, 138 | Inhibit differentiation of osteoprogenitors through attenuating Runx2 and Smad5 pathways | |
miR-141 and 200a | Down regulate BMP-2-induced pre-osteoblast differentiation through the translational repression of Dlx5 | |
miR-206 | Overexpression in osteoblast Inhibits their differentiation |
