Figure 1
From: Bone–cartilage crosstalk: a conversation for understanding osteoarthritis
Subchondral bone microarchitecture and osteoid seams characteristic of MRI identified bone marrow lesions (BMLs) in human tibial plateaus obtained at knee arthroplasty surgery for OA. No signal was detected on PDFS and T1-weighted MRI sequences for no-BML. BML signal was detected only by PDFS for BML 1; BML signal was detected by both PDFS and T1 for BML 2. Left panel shows three-dimensional reconstructed micro-computed tomography (CT) images of a 10 mm diameter cylindrical region of interest within the volume of the BML. Left and right middle panels show coronal and axial micro-CT images, respectively. Micro-CT images clearly demonstrate that BML subchondral bone is sclerotic, characterized by thicker subchondral bone plate, and increased trabecular bone volume with more plate-like structure. Right panel shows von Kossa silver/hematoxylin- and eosin-stained subchondral trabecular bone that shows BML tissue has increased osteoid, with increased osteoid seam thickness, and osteoid bridging and in-filling. The sclerotic subchondral bone phenotype characteristic of BMLs was more pronounced for BML 2 versus BML 1.16
