Figure 2 | Bone Research

Figure 2

From: Enhanced but hypofunctional osteoclastogenesis in an autosomal dominant osteopetrosis type II case carrying a c.1856C>T mutation in CLCN7

Figure 2

Hyperproliferation of peripheral blood mononuclear cells (PBMCs) from the type II autosomal dominant osteopetrosis (ADO2) patient. (a,b) Proliferating cells were cultured in the presence of macrophage-colony stimulating factor (M-CSF). More spindle-shaped cells were formed in PMBCs from the ADO2 patient (b) than from the control. (a,c,d) Cells were cultured in the absence of M-CSF. The control cells maintained their original circular shape. (c) ADO2 cells formed large numbers of spindle-shaped cells in colonies (arrows). (d,e) The ratio of spindle-shaped cells to total cells was significantly increased in the culture from the ADO2 patient.

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