Figure 4 | Bone Research

Figure 4

From: Enhanced but hypofunctional osteoclastogenesis in an autosomal dominant osteopetrosis type II case carrying a c.1856C>T mutation in CLCN7

Figure 4

Abnormal morphology and bone resorption in type II autosomal dominant osteopetrosis (ADO2) osteoclasts (OCs). Scanning electron microscope photomicrographs of cell morphology and pit formation. (a–c) Adherent cells from the control OC cultures. (d) Lacunar resorption after ultrasonic removal of the adherent cells in the control OC cultures. (e,f) Many adherent cells were observed in the ADO2 OC cultures. The adherent cells were irregularly spindle or stellate shaped (e-g). (h) Shallow lacunar resorption after ultrasonic removal of the adherent cells in the ADO2 OC culture.

Back to article page