Figure 4

Percentage changes in bone mineral density (BMD) of L1–4 lumbar vertebrae (L-BMD) (a) and bilateral total hips (H-BMD) (b) at the first visit and at 4, 8, 12, 18 and 24 months. Results are expressed as mean±s.e. †P<0.05, significant difference between the denosumab and combination groups at each time point. *P<0.05, **P<0.01, significant difference at 4, 8, 12, 15, 18 and 24 months compared with pretreatment in either the denosumab or combination group.