Figure 3
From: Atypical skeletal manifestations of rickets in a familial hypocalciuric hypercalcemia patient
Sites of known mutations and protein sequence alignment in the second extracellular loop of the model of CaSR. (a) Extracellular domain (ECD) of CaSR was shown in color diagram according to protein structure homology-modeling server (http://swissmodel.expasy.org/). The seven membrane spanning helices of CaSR are shown, based on hydropathy plot analysis (www.casrdb.mcgill.ca/). (b) Protein sequence alignment of the I760N mutation among different species, as given in the NCBI database.
