Abstract
Growing evidence points to the fact that glucose metabolism has a central role in carcinogenesis. Among the enzymes controlling this energy production pathway, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is of particular interest. Initially identified as a glycolytic enzyme and considered as a housekeeping gene, this enzyme is actually tightly regulated and is involved in numerous cellular functions. Particularly intriguing are recent reports describing GAPDH as a regulator of cell death. However, its role in cell death is unclear; whereas some studies point toward a proapoptotic function, others describe a protective role and suggest its participation in tumor progression. In this study, we highlight recent findings and discuss potential mechanisms through which cells regulate GAPDH to fulfill its diverse functions to influence cell fate.
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Abbreviations
- GAPDH:
-
glyceraldehyde-3-phosphate dehydrogenase
- CSF-1:
-
colony-stimulating factor-1
- H2B:
-
S-phase-dependent histone-2B
References
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Acknowledgements
We thank Dr. SW Tait (St. Jude Children’s Research Institute, Memphis, TN, USA) for critical reading of this paper. This work was supported in part by l’Association pour la Recherche sur le Cancer, by l’Agence Nationnal de la Recherche, la Fondation de France, Plan Nacional I+D SAF2008-04974 and by grants from The U.S. National Institutes of Health. J-E.R. is a recipient of a contrat d’interface INSERM-CHU de Nice.
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Colell, A., Green, D. & Ricci, JE. Novel roles for GAPDH in cell death and carcinogenesis. Cell Death Differ 16, 1573–1581 (2009). https://doi.org/10.1038/cdd.2009.137
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DOI: https://doi.org/10.1038/cdd.2009.137
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