Figure 6 | Cell Death & Differentiation

Figure 6

From: SOX2 has a crucial role in the lineage determination and proliferation of mesenchymal stem cells through Dickkopf-1 and c-MYC

Figure 6

Ectopic expression of DKK1 and WNT ligands cannot recover the proliferation defect caused by SOX2 knockdown in hUCB–MSCs. (a and b) Proliferation of hUCB–MSCs with lentiviral SOX2 knockdown did not increase after DKK1 treatment, as confirmed by the MTT assays and FACS analysis. *P<0.05; **P<0.01; ***P<0.001. (c and d) Treatment with WNT3A and WNT5A could not recover the proliferation defect in SOX2-knockdown hUCB–MSCs. **P<0.01; ***P<0.001

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