Abstract
CD95 (APO-1/Fas) is a member of the death receptor (DR) family. Stimulation of CD95 leads to induction of apoptotic and non-apoptotic signaling pathways. The formation of the CD95 death-inducing signaling complex (DISC) is the initial step of CD95 signaling. Activation of procaspase-8 at the DISC leads to the induction of DR-mediated apoptosis. The activation of procaspase-8 is blocked by cellular FLICE-inhibitory proteins (c-FLIP). This review is focused on the role in the CD95-mediated signaling of the death effector domain-containing proteins procaspase-8 and c-FLIP. We discuss how dynamic cross-talk between procaspase-8 and c-FLIP at the DISC regulates life/death decisions at CD95.
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Abbreviations
- DISC:
-
death-inducing signaling complex
- c-FLIP:
-
cellular FLICE-inhibitory proteins
- cyt C:
-
cytochrome C
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Acknowledgements
We acknowledge the Helmholtz Alliance on Systems Biology (NW1SBCancer/UniHD) and the Helmholtz-Russia Joint Research Groups-2008-2 for supporting our work. We thank Nicolai Fricker, Selcen Öztürk, Kolja Schleich and Claudia Weber for their critical comments.
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This article is dedicated to Jürg Tschopp.
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