Figure 11
From: Integration of CNS survival and differentiation by HIF2α
A proposed mechanism by which HIF2α deprivation induces NPC apoptosis and blocks neural differentiation. Knockdown of hif2α results in a reduction in the survivin orthologues, which in turn causes apoptosis and induces complementary proliferation in neighboring cells. The replenished proliferating cells remain in the cell cycle and do not terminally differentiate
