Figure 2

Multiple pathways of selective autophagy. (a) Atg11 is a key component of a number of selective autophagy routes, including the Cvt pathway, mitophagy, pexophagy and PMN. By contrast, Atg11 is dispensable for ribophagy and preferential Ald6 degradation. ‘Core’ Atg proteins function in the membrane biogenesis of Cvt vesicles/autophagosomes. (b) Schematic of Atg11-dependent selective autophagy. Atg11 functions as a scaffold protein for PAS formation by recruiting core Atg proteins. Autophagosomes are generated from the PAS and, subsequently, delivered to the vacuole, where the selected cargoes are degraded