Figure 2 | Cell Death & Differentiation

Figure 2

From: Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis

Figure 2

Novel p53-target genes bound by p53 and differentially expressed upon nultin3a treatment. (a) Bioinformatic analysis of the genes bound by p53 within 10 kbp from TSS and differentially expressed upon 8 h of nutlin3a treatment (P<0.05) revealed 280 putative novel p53-target genes. (b) A heatmap shows the differential expression of selected 280 p53-bound genes upon nutlin3a treatment. Columns indicate separate arrays and rows indicate genes. The values are row-mean-centered. Green corresponds to lower and red to higher than mean value expression. (c) The pie chart of the functional categories of 280 novel p53-target genes. (d) The p53 consensus binding site was detected much more often in the proximity of TSS of induced, than repressed genes (66% and 21%, respectively), as analyzed using the MEME algorithm. (e) The probability of the presence of a p53 consensus binding motif in the p53-bound fragment is higher in induced than in repressed genes

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