Figure 1 | Cell Death & Differentiation

Figure 1

From: When numbers matters: mitochondrial DNA and gliomagenesis

Figure 1

During differentiation, neural stem cells expand their mtDNA copy number in order to sustain mitochondrial biogenesis. Glioma stem cells, which might derive from adult neural stem cells or dedifferentiating astrocytes, have a reduced stem potential compared to neural stem cells possibly due to an incomplete nuclear reprogramming and a partial reduction of mtDNA copy number. Partial mtDNA depletion in GBM cells gives rise to cancer with later onset and subsequent faster growth compared to their 100% mtDNA GBM counterparts

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