Figure 7 | Cell Death & Differentiation

Figure 7

From: β-Catenin and NF-κB co-activation triggered by TLR3 stimulation facilitates stem cell-like phenotypes in breast cancer

Figure 7

Cardamonin abolishes tumor-initiating potential induced by poly(I:C) in vivo. (a) Schematic diagram of in vivo experimental approaches. Mammary fat pads of nude mice were inoculated with SUM190 cells. Once tumors reached an average size of 4 mm in diameter, the mice were randomized into six treatment groups as shown in the diagram. Poly (I:C) and/or cardamonin were injected intraperitoneally every other day. (bd) Although poly(I:C) injection retards tumor growth (b, tumor weight), it also significantly increases CSC pool. In contrast, co-injection of cardamonin abrogates poly(I:C)-enhanced CSC frequency (c), flow-cytometry analysis of CD44high/CD24−/low sub-population) and total CSCs in each tumor (d). Data represent the average±S.D., n=3–4; *P<0.05

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