Figure 6
From: Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo
Model of MYC regulation of apoptosis in response to DNA damage in the intestine. (a) In wild type, MYC-proficient mice, the intestinal epithelial cells respond to DNA damage by upregulating MYC, which then inhibits MDM2. This allows P53 levels to increase and induce apoptosis. (b) When MYC is deleted from the intestinal epithelial cells they can no longer inhibit MDM2 in response to DNA damage, and consequently P53 is not upregulated resulting in reduced apoptosis
